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| Registros recuperados: 15 | |
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| Noël,F.; Nascimento-Viana,J.B.; Romeiro,L.A.S.; Silva,R.O.; Lemes,L.F.N.; Oliveira,A.S.; Giorno,T.B.S.; Fernandes,P.D.; Silva,C.L.M.. |
| This study aimed to estimate the absorption, distribution, metabolism and excretion (ADME) properties and safety of LDT5, a lead compound for oral treatment of benign prostatic hyperplasia that has previously been characterized as a multi-target antagonist of α1A-, α1D-adrenoceptors and 5-HT1A receptors. The preclinical characterization of this compound comprised the evaluation of its in vitro properties, including plasma, microsomal and hepatocytes stability, cytochrome P450 metabolism and inhibition, plasma protein binding, and permeability using MDCK-MDR1 cells. De-risking and preliminary safety pharmacology assays were performed through screening of 44 off-target receptors and in vivo tests in mice (rota-rod and single dose toxicity). LDT5 is stable in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Benign prostatic hyperplasia; ADME; Safety; Permeability; CYP; Preclinical development. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001200603 |
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| Kratz,J.M.; Teixeira,M.R.; Koester,L.S.; Simões,C.M.O.. |
| The Caco-2 cell line has been used as a model to predict the in vitro permeability of the human intestinal barrier. The predictive potential of the assay relies on an appropriate in-house validation of the method. The objective of the present study was to develop a single HPLC-UV method for the identification and quantitation of marker drugs and to determine the suitability of the Caco-2 cell permeability assay. A simple chromatographic method was developed for the simultaneous determination of both passively (propranolol, carbamazepine, acyclovir, and hydrochlorothiazide) and actively transported drugs (vinblastine and verapamil). Separation was achieved on a C18 column with step-gradient elution (acetonitrile and aqueous solution of ammonium acetate, pH... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Caco-2; HPLC-UV; Marker drugs; Permeability. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000600006 |
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| SILVA, E. M. da; AZEVEDO, J. A. de; RAUBER, J. C.; REATTO, A.. |
| RESUMO: O plantio direto resulta em impactos positivos na conservação da água no solo. Considerando essa premissa, este trabalho teve o objetivo de avaliar as principais alterações nas propriedades físico-hídricas de solos de Cerrado, decorrentes do uso do plantio direto durante 3, 6 e 12 anos, sob condições de sequeiro e irrigado, em comparação com o plantio convencional e um ambiente de mata natural, na fezenda Ampessan, Cabeceiras, GO. As características físico-hídricas do solo foram avaliadas nas seguintes camadas: 0 a 5 cm; 2,5 a 7,5 cm; 5 a 10 cm; 10 a 15 cm; 20 a 25 cm; 42,5 a 47, 5 cm e 72,5 a 77,5 cm. As características de infiltração nesses ambientes foram avaliadas nas profundidades de 12 a 80 cm, utilizando o método do permeâmetro de Guelph... |
| Tipo: Boletim de Pesquisa e Desenvolvimento (INFOTECA-E) |
Palavras-chave: Plantio convencional; Soil chemicophysical properties; Zero tillage.; Condutividade Hidráulica; Cerrado; Física do Solo; Plantio Direto; Retenção de Água no Solo; Solo.; Permeability; Soil water retention.; Soil. |
| Ano: 2003 |
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/568975 |
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| Winters, W. J.; Wilcox-cline, R. W.; Long, P.; Dewri, S. K.; Kumar, P.; Stern, L.; Kerr, L.. |
| The sediment characteristics of hydrate-bearing reservoirs profoundly affect the formation, distribution, and morphology of gas hydrate. The presence and type of gas, porewater chemistry, fluid migration, and subbottom temperature may govern the hydrate formation process, but it is the host sediment that commonly dictates final hydrate habit, and whether hydrate may be economically developed. In this paper, the physical properties of hydrate-bearing regions offshore eastern India (Krishna-Godavari and Mahanadi Basins) and the Andaman Islands, determined from Expedition NGHP-01 cores, are compared to each other, well logs, and published results of other hydrate reservoirs. Properties from the hydrate-free Kerala-Konkan basin off the west coast of India are... |
| Tipo: Text |
Palavras-chave: Physical properties; Gas hydrate; Porosity; Atterberg limits; Consolidation; Permeability; Shear strength; Scanning electron microscopy. |
| Ano: 2014 |
URL: https://archimer.ifremer.fr/doc/00289/40036/38799.pdf |
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| Verselis,V.K.; Trexler,E.B.; Bukauskas,F.F.. |
| Connexin46 (Cx46) forms functional hemichannels in the absence of contact by an apposed hemichannel and we have used these hemichannels to study gating and permeation at the single channel level with high time resolution. Using both cell-attached and -excised patch configurations, we find that single Cx46 hemichannels exhibit some properties expected of half of a gap junction channel, as well as novel properties. Cx46 hemichannels have a large unitary conductance (~300 pS) and a relatively large pore as inferred from permeability to TEA. Both monovalent cations and anions can permeate, but cations are substantially more permeable. The open channel conductance shows marked inward rectification in symmetric salts. We find that the conductance and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Permeability; Channel gating; Connexin46; Patch clamp. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400003 |
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| Lacoue Labarthe, T; Warnau, A; Oberhansli, F; Teyssie, J; Koueta, Noussithe; Bustamante, Paco. |
| Cuttlefish eggs were exposed to background concentrations of dissolved Ag and Cd, using the radiotracers Ag-110m and Cd-109. At different time of the embryonic development (50 days), some eggs were placed in non-contaminating conditions. During the experiment, the uptake and depuration kinetics, and distribution of these metals among the egg compartments (i.e. eggshell, vitellus, peri-vitelline fluid and embryo) were assessed. In parallel, experiments were conducted with sub-lethal concentrations of stable Ag and Cd (2 and 1 mu g l(-1), respectively) to compare the metal behaviour at higher concentrations. From the spawning date up to I month of development, both metals were taken up efficiently by the eggs, reaching load/concentration ratio (LCR) of 1059... |
| Tipo: Text |
Palavras-chave: Cephalopod; Permeability; Eggshell; Embryo; Biokinetics; Silver; Cadmium. |
| Ano: 2008 |
URL: http://archimer.ifremer.fr/doc/2008/publication-3882.pdf |
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| Cano Vázquez, Anaid. |
| El chile piquín es una planta silvestre que presenta ciertos mecanismos para asegurar la perpetuación de la especie. Dentro de estos mecanismos se encuentra la latencia de sus semillas. La germinación de las semillas de chile piquín presenta problemas para siembras intensivas comerciales. En este trabajo se planteó: 1) comparar diversas colectas en cuanto a su capacidad germinativa; 2) indagar si la baja germinación se debe a impermeabilidad en la semilla o a alguna característica estructural de la semilla; 3) encontrar un tratamiento de preacondicionamiento que mejore la germinación de la semilla y 4) probar la germinación in vitro como un método alternativo para obtener plántula en un corto tiempo. Para prevenir la interferencia de microorganismos... |
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Palavras-chave: Germinación; Impermeabilidad; Latencia; Desinfección; Germination; Permeability; Dormancy; Disinfection; Fisiología Vegetal; Maestría. |
| Ano: 2013 |
URL: http://hdl.handle.net/10521/2114 |
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| Galdeano,Melicia Cintia; Wilhelm,Allan Eduardo; Mali,Suzana; Grossmann,Maria Victória Eiras. |
| The aim of this study was to investigate the effect of thickness (between 80 and 120 µm) on apparent opacity, water vapor permeability and mechanical properties (tensile and puncture) of oat starch films plasticized with glycerol, sorbitol, glycerol:sorbitol mixture, urea and sucrose. Films were stored under 11, 57, 76 and 90% relative humidity (RH) to study the mechanical properties. It was observed that the higher the thickness, the higher was the opacity values. Films without the plasticizer were more opaque in comparison with the plasticized ones. Glycerol:sorbitol films presented increased elongation with increasing thickness at all RH. Puncture force showed a strong dependence on the film thickness, except for the films plasticized with sucrose. In... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Plasticizers; Tensile; Puncture; Permeability; Opacity; Glycerol. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000400014 |
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| Mesquita, Glaucia Machado; Santos, Felipe Corrêa Veloso dos; Dores, Anne Louise; Correchel, Vladia. |
| The study aimed to evaluate the hydraulic conductivity using soil samples with undisturbed structure in the soil layers of 0-5, 5-10, 10-20, and 20-40 cm; 120 soil samples were collected. For the determination of hydraulic conductivity, the constant load permeameter was used. For geostatistical analysis, exploratory data analysis was performed using frequency histograms, determining the main measures of position and dispersion, verifying the trends for the construction of boxplot graphics, which allows the identification of discrepant points. The lowest and highest hydraulic conductivity values were found in the 20-40 cm and 0-5 cm soil layers, respectively; values commonly found in soils under forest conditions. Based on the results, we conclude when the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Soil physical quality indicator; Permanent preservation areas; Soil water; Permeability. |
| Ano: 2022 |
URL: http://periodicosonline.uems.br/index.php/agrineo/article/view/6532 |
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| Nicholson,B.J.; Weber,P.A.; Cao,F.; Chang,H.-C.; Lampe,P.; Goldberg,G.. |
| Although gap junction channels are still widely viewed as large, non-specific pores connecting cells, the diversity in the connexin family has led more attention to be focused on their permeability characteristics. We summarize here the current status of these investigations, both published and on-going, that reveal both charge and size selectivity between gap junction channels composed of different connexins. In particular, this review will focus on quantitative approaches that monitor the expression level of the connexins, so that it is clear that differences that are seen can be attributed to channel properties. The degree of selectivity that is observed is modest compared to other channels, but is likely to be significant for biological molecules that... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Intercellular channels; Permeability; Channel selectivity; Gap junctions. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400002 |
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| Registros recuperados: 15 | |
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